Diseases/Injuries of Serum therapy
- For All
Lonaprevive and sotrobimab – From SARs-CoV-2 specific neutralizing antibody to broad neutralizing antibody – from Dr. Joe Chiba
Changes in the treatment of venomous snake bites in Japan (from Dr. Atsushi Sakai)
- For medical professionals
Equine serum hypersensitivity test when using pit viper antivenom was summarized in collaboration with Meiji Seika Pharma, Inc./KM Biologics, Inc.
Production of domestic redback spider antitoxin and preclinical studies
Currently, the only facility in Japan capable of producing antitoxin and antiserum is KMB (formerly the Research Institute for Chemotherapy and Serotherapy, Kumamoto).
In the case of equine serum, equine immunoglobulin is purified from the serum or plasma obtained by immunizing equines and collecting their blood, which is then filled into vials and formulated.
Production process of
bovine antitoxin preparation (example)
Bovine immunization process
- Immunization (basic, additional)
- Blood collection
- Serum and plasma separation
Antivenom purification process
- Pepsin digestion
- Salting out, dialysis
- Stock solution preparation
- Final bulk preparation
- Lyophilization, sealing